Celina*

BENEFITS:

• Used to treat a wide range of serious bacterial infections, including those in the lungs, abdomen, urinary tract, and skin.
• It is particularly effective against infections caused by Gram-positive and Gram-negative bacteria, including multidrug-resistant strains.
• The combination of imipenem and cilastatin provides broad-spectrum antibiotic coverage and helps prevent the degradation of imipenem in the kidneys. 

HOW IT WORKS:

• Imipenem is a broad-spectrum beta-lactam antibiotic that inhibits bacterial cell wall synthesis, leading to cell lysis and death.
• Cilastatin is a renal dehydropeptidase inhibitor that prevents the breakdown of imipenem in the kidneys, ensuring higher and more sustained levels of the antibiotic in the body.

DIRECTIONS FOR USE:

• Administer via intravenous (IV) infusion as directed by your healthcare provider.
• The dosage and duration depend on the type and severity of the infection, as well as the patient’s medical condition.
• Follow the healthcare provider’s instructions regarding infusion rates and timing. Proper aseptic techniques should be used during administration to prevent infections. 

SIDE EFFECTS:

• Common: Nausea, vomiting, diarrhea, rash, and headache.
• Serious: Severe allergic reactions (e.g., rash, itching, swelling, difficulty breathing), seizures, kidney problems (elevated blood urea nitrogen or creatinine levels), and severe gastrointestinal symptoms (e.g., persistent diarrhea with blood or mucus).

Seek immediate medical attention if you experience any severe side effects. 

WARNINGS & PRECAUTIONS:

• Contraindications: CELINA* should not be used in patients with a known hypersensitivity to imipenem, cilastatin, or other beta-lactam antibiotics. It is contraindicated in those with severe renal impairment or a history of severe allergic reactions to carbapenems.
• Consultation: Inform your doctor about any other medications you are taking, including over-the-counter drugs and supplements. Discuss your medical history, especially if you have a history of kidney disease, seizures, or gastrointestinal issues.
• Interactions: Imipenem may interact with other medications, including other antibiotics and medications that affect kidney function. Consult your healthcare provider about potential drug interactions to prevent adverse effects.
• Storage: Store CELINA* at room temperature, away from light and moisture. Keep the injection solution out of reach of children and do not use if the solution is discolored or contains particles.
• Dosage Adherence: Adhere strictly to the prescribed dosage and treatment schedule. Do not alter or stop the medication without consulting your healthcare provider. Regular monitoring of kidney function and other parameters may be required during treatment to manage potential side effects. 

Note: Always consult your doctor before taking any medication.